Nano-CNS
®
These include our intra-nasal therapies: NT-401, a treatment for Traumatic Brain Injuries, NT-501, a treatment for ALS, and NT-601, a treatment for Erectile Dysfunction.
NT-301 (Parkinson's Disease Treatment)
NT-301 is a portable intranasal powder formulation designed for rapid, convenient, needle-free on-demand treatment of OFF episodes in people with Parkinson’s disease.
2+ hours
daily OFF time reported by Parkinson's patients
1.1 Million
people in the U.S. are living with Parkinson’s Disease
Phase 1 Trial Completed
Excellent safety, tolerability, and dose-dependent PK Profiles
Needle Fatigue
is the main reason why patients discontinue injection treatments for OFF episodes
NT-401 (TBI Treatment)
NT-401 is a portable intra-nasal riluzole powder formulation which enables rapid, non-invasive delivery, in the field, following a Traumatic Brain Injury.
533,000+
U.S. service members have been diagnosed with Traumatic Brain Injuries since 2000
No approved drugs
No FDA-approved pharmacologic treatment for Traumatic Brain Injury
70,000
deaths were caused by Traumatic Brain Injuries in 2021 in the US alone
​Time Matters
Brain injury begins at the moment of trauma, creating a critical window for early neuroprotective intervention
NT-601 (ED Treatment)
NT-601 is on-demand therapy for Erectile Dysfunction. The medication is administered intra-nasally, rather than orally, and is designed for rapid onset and longer time at efficacious level.
30–50 Million
men in the U.S. are estimated to experience erectile dysfunction
1 in 4 men
experience ED by age 40
30 minutes
is the average onset of oral tadalafil tablets
Rapid & on-demand
​NT-401 is being developed as a portable intranasal powder designed to deliver neuroprotective therapy rapidly after traumatic brain injury
NT-901 (Ketamine Pain Relief)
NT-901 is a portable intranasal ketamine powder formulation. TransformaBio is developing it for rapid, needle-free treatment of acute traumatic pain in emergency, prehospital, and austere-care settings.
Needle-Free
intranasal delivery can provide analgesic treatment without establishing IV access or an injection
Field-Ready
NT-901 is being developed as a portable dry-powder product for rapid administration
Opioid-Sparing
ketamine offers a non-opioid approach to acute pain management
​52.6% Ketamine
By 2019, ketamine accounted for more than half of pain-medication administrations in U.S. military combat operations