Nano-CNS
®
These include our intra-nasal therapies: NT-401, a treatment for Traumatic Brain Injuries, NT-501, a treatment for ALS, and NT-601, a treatment for Erectile Dysfunction.
NT-301 (Parkinson's Disease Treatment)
NT-301 is a portable intranasal powder formulation designed for rapid, convenient, needle-free on-demand treatment of OFF episodes in people with Parkinson’s disease.
2+ hours
daily OFF time reported by Parkinson's patients
1.1 Million
people in the U.S. are living with Parkinson’s Disease
Phase 1 Trial Completed
Excellent safety, tolerability, and dose-dependent PK Profiles
Needle Fatigue
is the main reason why patients discontinue injection treatments for OFF episodes
OFF episodes (or "off time") are periods when Parkinson's Disease symptoms return or worsen because current medications (such as Levodopa) are not working at optimal levels between doses.
NT-401 (TBI Treatment)
NT-401 is a portable intra-nasal riluzole powder formulation which enables rapid, non-invasive delivery, in the field, following a Traumatic Brain Injury.
533,000+
U.S. service members have been diagnosed with Traumatic Brain Injuries since 2000
No approved drugs
No FDA-approved pharmacologic treatment for Traumatic Brain Injury
70,000
deaths were caused by Traumatic Brain Injuries in 2021 in the US alone
​Time Matters
Brain injury begins at the moment of trauma, creating a critical window for early neuroprotective intervention
NT-601 (ED Treatment)
NT-601 is on-demand therapy for Erectile Dysfunction. The medication is administered intra-nasally, rather than orally, and is designed for rapid onset and longer time at efficacious level.
30–50 Million
men in the U.S. are estimated to experience erectile dysfunction
1 in 4 men
experience ED by age 40
30 minutes
is the average onset of oral tadalafil tablets
Rapid & on-demand
​NT-401 is being developed as a portable intranasal powder designed to deliver neuroprotective therapy rapidly after traumatic brain injury
NT-901 (Ketamine Pain Relief)
NT-901 is a portable intranasal ketamine powder formulation. TransformaBio is developing it for rapid, needle-free treatment of acute traumatic pain in emergency, prehospital, and austere-care settings.
Needle-Free
intranasal delivery can provide analgesic treatment without establishing IV access or an injection
Field-Ready
NT-901 is being developed as a portable dry-powder product for rapid administration
Opioid-Sparing
ketamine offers a non-opioid approach to acute pain management
​52.6% Ketamine
By 2019, ketamine accounted for more than half of pain-medication administrations in U.S. military combat operations